Friday, July 26, 2019

A paradoxical proinflammatory effect of endocannabinoids in the brain discovered

News from DCEXS-UPF

A new study led by the Neuropharmacology Laboratory -NeuroPhar at UPF shows that increasing endocannabinoids in the brain may cause inflammation in specific brain areas such as the cerebellum, which is associated with problems of fine motor coordination. The results of the study in mice are contrary to what had been observed to date in other areas of the brain where endocannabinoids play an anti-inflammatory role. 

One of the beneficial effects of cannabinoids are their anti-inflammatory properties, which can be useful for treating inflammatory diseases that develop in the brain. In this new study the team of researchers led by Andrés Ozaita, the results show that in the cerebellum the opposite occurs from in the rest of the brain because increasing endocannabinoids increases inflammation, and this leads to motor coordination problems in the rodents.

The present study reveals the sensitivity of the cerebellum to changes in the signalling of the endocannabinoid system, compared with other areas of the brain like the hippocampus.



Sara Martínez-Torres, et al. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Brain, Behavior, and Immunity, July 2019. DOI: 10.1016/j.bbi.2019.06.036.

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