divendres 28 de juny de 2019

Mathematicians calculate the number of immune cells needed to thwart HIV progress

News from DCEXS-UPF

An international team of researchers have used the data on the mobility of immune T-cells to design a mathematical model in order to predict the number of them needed to be present in one lymph node to block further progress of Human Immunodeficiency Virus (HIV). The study has been led by Russian researchers at the Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences and involves Andreas Meyerhans, ICREA research professor at UPF.

"In the future, a model of this kind will enable scientists to carry out computer experiments for the development of vaccines and medicines for infectious diseases. The mechanism of cell migration under the influence of forces that ensure their autonomous movement, and the mechanism of intercellular interaction are quite universal, - said Gennady Bocharov, coordinator of the study. - “But each specific infection will require some parameters of the model to be adjusted, using appropriate experimental and clinical data. In addition to infectious diseases, the model can be useful in the study of malignant tumors."


Grebennikov Dmitry, Bouchnita Anass, Volpert Vitaly, Bessonov Nikolay, Meyerhans Andreas, Bocharov Gennady. Spatial Lymphocyte Dynamics in Lymph Nodes Predicts the Cytotoxic T Cell Frequency Needed for HIV Infection Control. Frontiers in Immunology, June 2019. DOI: 10.3389/fimmu.2019.01213.     


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