dimecres 5 de desembre de 2018

A study describes the dynamics of chromatin during organ and tissue regeneration

News from CRG

Researchers discover the genes and regulatory elements of their expression that are required during the process of tissue and organ regeneration in Drosophila melanogaster. The study, which appears on the cover of the prestigious journal Genome Research, combines the classic genetic analysis with the new study techniques for chromatin through next-generation sequencing.

Cecilia C Klein and Roderic Guigó, both researchers from the CRG, co-authored the article.

The authors analysed the transcriptome of imaginal disks in the Drosophila melanogaster’s wing in different regeneration time periods. Through the analysis of massive RNA sequencing, they identified those genes that are differentially expressed during the process. Thanks to the comparative analysis conducted on other species (mice and zebra fish), the authors discovered a group of genes involved in regeneration and which are conserved in all those species.

In this study, researchers also found out for the first time, three kinds of regulatory elements that are related to regeneration.


Vizcaya-Molina E, Klein CC, Mishra RK, Serras F, Guigo R, Corominas M. 2018. ”Damage responsive elements in Drosophilaregeneration”. November 20, 2018. Doi: 10.1101/gr.233098.117

More information:
CRG website